Clinical features of irritable bowel syndrome

Rome IV diagnostic criteria: Recurrent abdominal pain/discomfort for at least 1 day/week for past 3 months and at least 2 of the following: Related to defecation (improves or worsens) Change in stool frequency Change in stool form Alarm features (make you consider an etiology other than IBS): Older age of onset (over 50) Gastrointestinal bleeding Nocturnal diarrhea Worsening pain Iron deficiency anemia Elevated C-reactive protein Positive lactoferrin or calprotectin Family history of early colon cancer or IBD