Celecoxib (Celebrex) and other COX-2 Selective Inhibitors

We know that NSAIDs can inhibit both COX-1 and COX-2 enzymes. But these enzymes perform slightly different functions, and it seems that inhibition of COX-2 leads to the beneficial affects of NSAIDs while inhibition of COX-1 leads to the unwanted side effects. Well what if we could take advantage of slight discrepancies in the two active sites to inhibit only one enzyme and not the other? In fact it's been done! However, so far the results are not as promising as hoped. In fact, one such drug, Vioxx, was the subject of the largest drug recall in history. Let's get a closer look at this and other COX-2 selective inhibitors. Script by Chris Hofmann Watch the whole Pharmacology playlist: http://bit.ly/ProfDavePharma General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs Immunology Tutorials: http://bit.ly/ProfDaveImmuno EMAIL► [email protected] PATREON►   / professordaveexplains   Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience! Amazon: https://amzn.to/2HtNpVH Bookshop: https://bit.ly/39cKADM Barnes and Noble: https://bit.ly/3pUjmrn Book Depository: http://bit.ly/3aOVDlT