Who Is Scoring Tonight? Jo's MNF TD Play for 49ers vs Panthers

If you are looking for a NFL Week 12 betting preview with picks and predictions for the Carolina Panthers vs San Francisco 49ers Monday Night Football matchup, we have you covered! Our NFL handicapping experts discuss this matchup from a sports betting perspective, sharing their picks and predictions vs. the current odds. #nflpredictions #nflfreepicks #nflpicks 📣 Game Preview — Monday, November 24, 2025 Week 12 brings a Monday Night Football showdown as the Carolina Panthers head west to face the San Francisco 49ers in Santa Clara. 🏈 Teams & Nicknames San Francisco 49ers (the Niners) Carolina Panthers (the Panthers) 📍 Location Levi’s Stadium — Santa Clara, California 📺 How to Watch Live on ESPN Kickoff: 8:15 PM ET 📊 Current Betting Line Spread: 49ers –7 Total (Over/Under): 48.5 points 📌 Team Twitter Tags 49ers: @49ers — #49ers Panthers: @Panthers — #KeepPounding 🔍 Interesting Facts & Notable Notes The 49ers enter this matchup averaging just under 24 points per game with a balanced offensive approach. The Panthers come in with a younger roster and an offense showing flashes of improvement in yardage and pace. This marks Carolina’s first visit to Levi’s Stadium in several seasons. San Francisco has historically performed well in Monday night matchups, especially at home. Both teams feature emerging playmakers who have taken on larger roles throughout the season. Get the hottest sports betting picks, odds, and predictions daily. It's about all the Picks & Parlays as we put the money in your pocket. 👍 Make sure to SUBSCRIBE to Picks and Parlays TV; 🔔 CLICK the Bell and never miss an episode! 🤑 Free Sports Picks: https://picksandparlays.net/free-spor... 📊 Live Odds: https://picksandparlays.net/odds 📰 News: https://picksandparlays.net/free-picks/ 👍 Stay connected with Picks and Parlays 📺 YouTube:    / @picksparlays   🐦 Twitter: https://x.com/PicksParlays #PicksAndParlays #SportsBettingPicks #PicksParlays