The Science of CRISPR

And the #NobelPrize2020 goes to…#CRISPR. Eight years after the discovery of this revolutionary technology, the field has made leaps and bounds in the application of this science. CRISPR is a pair of molecular scissors, that allows the precise editing of virtually any gene in the genome. Here's how it works. More videos coming soon. Please rate☝️, comment👇, and subscribe☝️ if you like them, so that I can make more! Please send through requests for topics to cover as well. What do you want to learn about? #scienceinmotion   Music thanks to:   Music by Adam Vitovský DOWNLOAD LINK: http://www.adamvitovsky.com/care Creative Commons — Attribution 3.0 Unported — CC BY 3.0   Images thanks to:   Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License   Emmanuelle Charpentier & Jennifer Doudna. Adapted from WikiCommons. Available from: https://commons.wikimedia.org/wiki/Fi... Creative Commons — Attribution 3.0 Unported — CC BY 3.0   Some images designed by Freepik/brgfx/Makyzz/vectorpouch/ upklyak. Available from: www.freepik.com Germline modification regulations. The Conversation. Available from: https://theconversation.com/a-case-ag... Creative Commons — Attribution 3.0 Unported — CC BY 3.0 Some images adapted from BioRender. Created with BioRender.com.   References:   Alagoz M, Kherad N. Advance genome editing technologies in the treatment of human diseases: CRISPR therapy (Review). Int J Mol Med. 2020;46(2):521-34. Jiang F, Doudna JA. CRISPR-Cas9 Structures and Mechanisms. Annu Rev Biophys. 2017 May 22;46:505-529. doi: 10.1146/annurev-biophys-062215-010822. Epub 2017 Mar 30. PMID: 28375731. Uddin F, Rudin CM, Sen T. CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future. Front Oncol. 2020;10:1387-.   Li H, Yang Y, Hong W, Huang M, Wu M, Zhao X. Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects. Signal Transduction and Targeted Therapy. 2020;5(1):1.   Araki M, Ishii T. International regulatory landscape and integration of corrective genome editing into in vitro fertilization. Reproductive Biology and Endocrinology. 2014;12(1):108.   Hsu Patrick D, Lander Eric S, Zhang F. Development and Applications of CRISPR-Cas9 for Genome Engineering. Cell. 2014;157(6):1262-78.