Classification of Glomerular Injuries or Glomerulopathies (Primary, Secondary, Hereditary)

Glomerular injuries or glomerulopathies can be classified based on their underlying pathogenesis and histopathological features. Here's a broad classification: 1. Immune Complex-Mediated Glomerulonephritis (ICGN) Description: Caused by the deposition of antigen-antibody complexes in the glomeruli. Examples: Lupus nephritis, IgA nephropathy, post-infectious glomerulonephritis, and membranous nephropathy. 2. Pauci-Immune Glomerulonephritis Description: Characterized by minimal or no immune deposits in the glomeruli. Examples: ANCA-associated vasculitis (e.g., granulomatosis with polyangiitis, microscopic polyangiitis). 3. Anti-Glomerular Basement Membrane (Anti-GBM) Glomerulonephritis Description: Caused by antibodies directed against the glomerular basement membrane. Example: Goodpasture syndrome. 4. Monoclonal Immunoglobulin (Ig) Deposition Disease Description: Involves the deposition of monoclonal immunoglobulins in the glomeruli. Examples: Light chain deposition disease, heavy chain disease. 5. C3 Glomerulopathy Description: Characterized by predominant C3 deposition in the glomeruli with little or no immunoglobulin involvement. Examples: Dense deposit disease, C3 glomerulonephritis. 6. Other Specific Glomerulopathies Description: Includes various other glomerular diseases with distinct pathogenetic mechanisms. Examples: Focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), and diabetic nephropathy. #GlomerularInjuries #Glomerulopathies