Play that Clotting Cascade Med Kids

Jeff L. Staudinger, PhD: Division of Basic Sciences Topic/Lecture Name: The Clotting Cascade The following resource will assist you in addressing the DSA objectives in preparation for lecture: Required Reading Assignment: Robbins and Cotran, Pathologic Basis of Disease (10th ed.), Kumar, Vinay. Sections from Chapter 4 entitled: • Hemostasis, Hemorrhagic Disorders, and Thrombosis • Normal Hemostasis • Hemorrhagic Disorders • Thrombosis STUDENT LEARNING OBJECTIVES: After reviewing the relevant reading material and studying the lecture notes students should come to class prepared to: 1. Compare and contrast the physiologic sequence of steps in the intrinsic and extrinsic pathways of secondary hemostasis.  Identify the major proteins involved in each pathway.  Explain the trigger for initiating the extrinsic and intrinsic pathways of coagulation cascade and contrast the relative roles of each pathway. 2. Compare and contrast hemostasis, clot, hemostatic plug, coagulation & coagulation cascade.  Memorize the sequence of events that occurs during the clotting cascade.  Analyze the specific reactions in the coagulation pathway. 3. Compare and contrast the physiologic roles of fibrinogen, thrombin & fibrin.  Define the role of thrombin in the generation of fibrin from fibrinogen.  Explain the central role of thrombin and its 3 major actions in clot formation. 4. Dissect the role of Vitamin K in the clotting cascade.  Memorize the Vitamin K-dependent clotting factors, and describe the clinical causes and outcome of a vitamin K deficiency. 5. Establish the molecular mechanism of how the drug Warfarin impacts the clotting cascade. 6. Identify the precise relationship between Factor VIII and Hemophilia.