5. Anemia Of Chronic Disease Hindi: Pathology Lectures

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 :   / clinical.learning   Anemia Of Chronic Disease Hindi: Pathology Lectures - ------------------------------------------------------------------------------------------- Anemia of Chronic Disease (ACD), also called anemia of inflammation, is a common type of anemia associated with chronic illnesses such as infections, autoimmune diseases (e.g., rheumatoid arthritis, lupus), malignancies, and chronic kidney disease. The underlying pathology involves altered iron metabolism, reduced erythropoiesis, and shortened RBC lifespan, driven by chronic inflammation. Inflammatory cytokines like interleukin-6 (IL-6) stimulate the production of hepcidin, a liver-derived hormone that blocks iron release from macrophages and suppresses intestinal iron absorption. This leads to functional iron deficiency, where adequate iron stores are present but unavailable for hemoglobin synthesis. Additionally, erythropoietin production is often inadequate, particularly in renal disease, further reducing RBC production. Clinically, ACD manifests with fatigue, weakness, pallor, and symptoms of the underlying disease. Laboratory findings include low serum iron, normal or increased ferritin, and low transferrin saturation, distinguishing it from iron-deficiency anemia. Treatment focuses on managing the underlying condition, correcting iron deficiency if coexistent, and in severe cases, administering erythropoiesis-stimulating agents (ESAs) or blood transfusions. 🩸✨📚 #AnemiaOfChronicDisease #PathologyLectures #HematologyBasics #IronMetabolism #InflammationAndAnemia #MBBSNotes #StudySmart #MedicalEducation