Why You’re Anxious, Wired & Sleepless: Could It Be Histamine?
If you’ve been battling anxiety, irritability, insomnia, or brain fog, and nothing seems to help, it might not be all in your head. It could be histamine intolerance. Yes, histamine isn't just about allergies. It’s also a powerful neurotransmitter that affects your mental health in profound ways. In this video, I’ll walk you through how certain genetic variants like DAO, HNMT, MAO, COMT, and MTHFR can impair your ability to break down histamine, leading to hidden inflammation, sleep issues, racing thoughts, and mood dysregulation. 👩⚕️ I’m Jezel Rosa, board-certified psychiatric nurse practitioner and founder of Levelheaded Mind. I combine functional medicine, genetic testing, and holistic strategies to help you optimize your brain health naturally, using a skills before pills approach. 🧬DNA Testing packages: https://2ly.link/261YY 🧪 Mental Health Lab Testing: https://2ly.link/261YZ 💊Personalized supplements- https://tidd.ly/45B3elj 📚 Recommended Reading: https://www.levelheadedmind.com/books 🎥 This video was edited by: Rahul Kanchi / rahul-kanchi 🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor. You can find a list of international crisis lines here: https://blog.opencounseling.com/suici... References: García-Martín, E., Navarro-Muñoz, S., Amo, G., Rodríguez, C., Serrador, M., Alonso-Navarro, H., ... & García-Ruiz, R. (2022). Increased serum diamine oxidase activity in nonallergic patients with migraine. European Journal of Clinical Investigation, 52, e13757. https://doi.org/10.1111/eci.13757 Hamada, Y., Shinohara, Y., Yano, M., Yamamoto, M., Yoshio, M., Satake, K., Toda, A., Hirai, M., & Usami, M. (2013). Effect of the menstrual cycle on serum diamine oxidase levels in healthy women. Clinical Biochemistry, 46(1–2), 99–102. https://pubmed.ncbi.nlm.nih.gov/23099... Hauer, J. (2023). Histamine intolerance: The current state of the art. Nutrients. https://www.ncbi.nlm.nih.gov/pmc/arti... Moon, D. (2025, June 5). Histamine intolerance: Understanding genes, managing symptoms. Genetic Lifehacks. https://www.geneticlifehacks.com/hist... Miyoshi, M., Ueno, M., Matsuo, M., Hamada, Y., Takahashi, M., Yamamoto, M., Yamamoto, I., Mikajiri, R., Tabuchi, S., Wakida, K., Yamanishi, M., Hirai, M., & Usami, M. (2017). Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women. Nutrition, 39–40, 67–70. https://doi.org/10.1016/j.nut.2017.03... Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment. Note: This video is not sponsored. Some of the links provided are affiliate links, meaning I may earn a small commission from purchases made through those links.
