Cholinergic Agonists Acetylcholine Neostigmine Parathion

Cholinergic agonists are a class of drugs that mimic the action of acetylcholine, a neurotransmitter in the nervous system. These drugs activate cholinergic receptors, leading to various effects such as increased muscle contraction, enhanced glandular secretions, and slowed heart rate. Cholinergic agonists are used therapeutically to treat conditions like glaucoma, urinary retention, and dry mouth. However, they can also cause side effects like excessive sweating, bradycardia, and gastrointestinal distress. Understanding their mechanism of action is crucial for their safe and effective use in clinical practice. Timecodes 0:00 Intro 2:01 Synthesis and release of Acetylcholine 9:37 Cholinergic Agonists Category 15:43 Cholinoceptors Characteristics 19:29 Cholinoceptors Distribution 21:08 Muscarinic receptors 22:29 Acetylcholine (Ach)-muscarinic actions 27:50 Nicotinic receptors 30:12 Mnemonic that captures the muscarinic effects 31:08 Direct-acting (Cholinomimetic Agents) 38:35 Direct-acting cholinomimetic agents Table 39:57 Adverse Effects of Cholinergic Agonists 41:36 Pharmacologic targets in the eye 44:36 Anticholinesterases (Reversible) 46:00 Acetylcholinesterase (AChE) 46:34 AChEIs Image and list of agents 55:38 Physostigmine vs. Neostigmine 57:05 Myasthenia Gravis 57:53 Alzheimer disease Treatment 1:01:24 Anticholinesterases (Irreversible) 1:03:21 Major Signs and Symptoms of Organophosphate Insecticide Poisoning 1:06:06 How to treat organophosphate toxicity