6. Pharmacokinetics: Distribution (Part-3): General Pharmacology Lectures

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 :   / clinical.learning   Pharmacokinetics: Distribution (Part-3) - ------------------------------------------------------------------ Pharmacokinetics - Distributionfocuses on the role of specialized barriers and redistribution in drug movement across the body. Barriers like the blood-brain barrier (BBB) 🧠 and placental barrier 👶 selectively regulate drug penetration to protect critical regions. Lipophilic drugs cross these barriers more easily, while hydrophilic and ionized drugs often require transport mechanisms. Redistribution is another key aspect, where a drug initially accumulates in highly perfused tissues (e.g., brain, liver) and later redistributes to less perfused tissues (e.g., fat, muscle) 🩸. This phenomenon significantly impacts the duration of drug action. For example, anesthetics like thiopental exhibit rapid onset due to brain distribution but are later redistributed, shortening their effect. Factors like protein binding, tissue storage, and regional blood flow influence both barriers and redistribution, making them pivotal in determining drug efficacy and safety 🚑. #Pharmacokinetics #DrugDistribution #BloodBrainBarrier #PlacentalBarrier #Redistribution #DrugEfficacy #PharmaMadeEasy #MBBSPharmacology #MedicalEducation #MedStudentLife #ClinicalPharmacology #USMLEPrep #BoardExamPrep #DrugAction #PharmacologyStudy #TherapeuticDrugs