Diclofenac | Dicloran/Voren | Mechanism of Action |Dosage| Indications |Adverse Effect (Hindi/Urdu)

What is Diclofenac Sodium/ Potassium ?. How to Use Diclofenac Sodium/Potassium ? What are the uses Diclofenac Sodium ? What are adverse effects of Diclofenac sodium ? What is dose of Diclofenac Sodium ? Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signaling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. It is often used in combination with misoprostol to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren, marketed by Novartis. Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. LEARNING OUTCOMES • Name • Introduction • Description • Contents (Dosage form + Strength) • Pharmacology • Mechanism of Action • Absorption • Distribution • Metabolism • Excretion • Bio pharmaceutics-of drug • Indication • Services level category • Dosage • Administration • Contraindication • Precaution • Toxicity • Pregnancy • Lactation • Interaction • Adverse effect • Brand name • References Contacts : Facebook Link:   / pharmanerdlectures   Twitter Link:   / realtalhameraj   Instagram Link:   / pharmanerd1   #diclofenac #pharmanerd #DrMuhammadTalhaMeraj